mithramycin
anticancer agents
structure elucidation
Streptomyces argillaceus
hybrid natural products
biosynthetic intermediates
tricyclic intermediate
genetic recombination
polyketide biosynthesis
type II polyketide synthase
anticancer natural products
enantiospecific synthesis
dihydropyridines
chiral enamines
asymmetric synthesis
pyridine synthesis
actinomycetes
combinatorial biosynthesis
natural product discovery
secondary metabolites
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