Die antitumorwirksame Hybrid-Verbindung Premithramycinon H verweist indirekt auf ein tricyclisches Intermediat der Biosynthese des Aureolsäure-Antibiotikums Mithramycin Felipe Lombó Eva Künzel Laura Prado Alfredo F. Braña Kai U. Bindseil Jürgen Frevert Daniel W. Bearden Cármen Méndez José A. Salas Jürgen Rohr mithramycin hybrid natural products biosynthetic intermediates tricyclic intermediate genetic recombination anticancer agents structure elucidation Gen-Rekombinationsexperimente sind nicht nur nützlich für die Herstellung neuer Hybrid-Naturstoffe, sondern können auch hilfreich sein, um instabile Biosynthese-Zwischenprodukte abzufangen und Rückschlüsse auf deren Struktur zu ermöglichen. Premithramycinon H 1, ein biologisch aktives Hybridprodukt, das aus einer Mischung von Mithramycin- mit Tetracenomycin-Biosynthesegenen hervorgeht, ist hierfür ein gutes Beispiel. 2000 de info:eu-repo/semantics/article journal-article https://doi.org/10.1002/(sici)1521-3757(20000218)112:4<808::aid-ange808>3.0.co;2-3 Angewandte Chemie Angewandte Chemie urn:issn:0044-8249 urn:issn:0932-2140 Angewandte Chemie, 2000, vol. 112, n. 4, p. 808-811 info:eu-repo/semantics/closedAccess closedAccess Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin Felipe Lombó Eva Künzel Laura Prado Alfredo F. Braña Kai U. Bindseil Jürgen Frevert Daniel W. Bearden Cármen Méndez José A. Salas Jürgen Rohr mithramycin hybrid natural products genetic recombination biosynthetic intermediates tricyclic intermediate structure elucidation anticancer agents Gene recombination experiments are not only useful for the generation of novel hybrid natural products, but can also be helpful in intercepting unstable biosynthetic intermediates to allow conclusions to be made about their structures. Premithramycinone H (1), a biologically active hybrid which results from a mixture of mithramycin and tetracenomycin biosynthetic genes, is a good example of this strategy. 2000 en info:eu-repo/semantics/article journal-article https://doi.org/10.1002/(sici)1521-3773(20000218)39:4<796::aid-anie796>3.0.co;2-n Angewandte Chemie International Edition Angewandte Chemie International Edition urn:issn:1433-7851 urn:issn:1521-3773 Angewandte Chemie International Edition, 2000, vol. 39, n. 4, p. 796-799 info:eu-repo/semantics/closedAccess closedAccess Q1 pubmed Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal ChemInform Abstract: Enantiospecific Synthesis of Dihydropyridines from Chiral Enamines. Esther Caballero Pilar Puebla M. SANCHEZ Manuel Medarde Laura Prado Arturo San Feliciano enantiospecific synthesis dihydropyridines chiral enamines asymmetric synthesis pyridine synthesis Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 1996 en info:eu-repo/semantics/article journal-article https://doi.org/10.1002/chin.199647137 ChemInform ChemInform urn:issn:0009-2975 urn:issn:0931-7597 ChemInform, 1996, vol. 27, n. 47 info:eu-repo/semantics/closedAccess closedAccess Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis J. A. Salas Gloria Blanco Alfredo F. Braña Ernestina Fernández Ma José Palomo Fernández Jose Garcia Bernrdo Ana Gonzalez Felipe Lombó Laura Prado Luís M. Quirós César Sánchez Cármen Méndez anticancer agents actinomycetes combinatorial biosynthesis natural product discovery secondary metabolites anticancer drug discovery 2001 en info:eu-repo/semantics/bookPart book-chapter https://doi.org/10.1007/0-306-46885-9_23 Focus on biotechnology Focus on biotechnology urn:issn:1569-268X Focus on biotechnology, 2001, p. 383-399 info:eu-repo/semantics/openAccess openAccess cc-by-nc-nd http://hdl.handle.net/10651/30839 Good health and well-being Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties Aída González Lily L. Remsing Felipe Lombó M. J. Fernández Laura Prado Alfredo F. Braña Eva Künzel Jürgen Rohr Cármen Méndez José A. Salas mithramycin Streptomyces argillaceus sugar synthesis glycosylation C-methyltransferase polyketide biosynthesis glycosyltransferases insertional inactivation 2001 en info:eu-repo/semantics/article journal-article https://doi.org/10.1007/s004380000372 Molecular & General Genetics: MGG Molecular & General Genetics: MGG urn:issn:1617-4615 urn:issn:1617-4623 Molecular & General Genetics: MGG, 2001, vol. 264, n. 6, p. 827-835 info:eu-repo/semantics/openAccess openAccess cc-by-nc-nd http://hdl.handle.net/10651/40166 Q1 pubmed Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus Laura Prado Felipe Lombó Alfredo F. Braña Cármen Méndez Jürgen Rohr José A. Salas mithramycin type II polyketide synthase Streptomyces argillaceus polyketide biosynthesis oxygenase reductase gene replacement biosynthetic gene clusters anticancer natural products biosynthetic pathway 1999 en info:eu-repo/semantics/article journal-article https://doi.org/10.1007/s004380050960 Molecular & General Genetics: MGG Molecular & General Genetics: MGG urn:issn:0026-8925 urn:issn:1432-1874 Molecular & General Genetics: MGG, 1999, vol. 261, n. 2, p. 216-225 info:eu-repo/semantics/closedAccess closedAccess pubmed Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin Laura Prado Ernestina Fernández Ulrike Weiβbach Gloria Blanco Luís M. Quirós Alfredo F. Braña Cármen Méndez Jürgen Rohr José A. Salas oxidative cleavage Streptomyces argillaceus Baeyer-Villiger oxidation lactone ring opening type II polyketide synthase anticancer natural products 1999 en info:eu-repo/semantics/article journal-article https://doi.org/10.1016/s1074-5521(99)80017-9 CHEMISTRY & BIOLOGY CHEMISTRY & BIOLOGY urn:issn:1074-5521 urn:issn:1879-1301 CHEMISTRY & BIOLOGY, 1999, vol. 6, n. 1, p. 19-30 info:eu-repo/semantics/openAccess openAccess https://doi.org/10.1016/s1074-5521(99)80017-9 pubmed Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal The structures of premithramycinone and demethylpremithramycinone, plausible early intermediates of the aureolic acid group antibiotic mithramycin Jürgen Rohr Ulrike Weißbach Claus Beninga Eva Künzel Karsten Siems Kai U. Bindseil Felipe Lombó Laura Prado Alfredo F. Braña Cármen Méndez José A. Salas mithramycin antibiotic biosynthesis structure elucidation The structures of premithramycinone and its demethyl analogue suggest that the aureolic acid antibiotics are biosynthetically formed via a tetracycline-type, and not a tetracenomycin-type, folded decaketide. 1998 en info:eu-repo/semantics/article journal-article https://doi.org/10.1039/a707446h Chemical Communications Chemical Communications urn:issn:1359-7345 urn:issn:1364-548X Chemical Communications, 1998, n. 3, p. 437-438 info:eu-repo/semantics/openAccess openAccess cc-by-nc-nd http://hdl.handle.net/10651/42620 Q1 Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal Towards the generation of novel antitumour agents from actinomycetes by combinatorial biosynthesis 2001 info:eu-repo/semantics/article journal-article cris:cris-6b76f078 NOVEL FRONTIERS IN THE PRODUCTION OF COMPOUNDS FOR BIOMEDICAL USE, VOL 1 NOVEL FRONTIERS IN THE PRODUCTION OF COMPOUNDS FOR BIOMEDICAL USE, VOL 1 NOVEL FRONTIERS IN THE PRODUCTION OF COMPOUNDS FOR BIOMEDICAL USE, VOL 1, 2001 Instituto Universitario de Investigación Padre Ossó https://www.facultadpadreosso.es/investigacion/portal